Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

Proteolytic processing of the β-amyloid precursor protein (APP) at the β site is essential to generate Aβ. BACE1, the major β-secretase involved in cleaving APP, has been identified as a type 1 membrane-associated aspartyl protease. We have cloned a 2.1-kb fragment upstream of the human BACE1 gene a...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Christensen, Michelle A., Zhou, Weihui, Qing, Hong, Lehman, Anna, Philipsen, Sjaak, Song, Weihong
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
Ämnen:
Transcriptional Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC343820/
https://ncbi.nlm.nih.gov/pubmed/14701757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.2.865-874.2004
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk