MSH2-Dependent Germinal CTG Repeat Expansions Are Produced Continuously in Spermatogonia from DM1 Transgenic Mice

Myotonic dystrophy type 1 is a neuromuscular affection associated with the expansion of an unstable CTG repeat in the DM protein kinase gene. The disease is characterized by somatic tissue-specific mosaicism and very high intergenerational instability with a strong bias towards expansions. We used t...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Savouret, Cédric, Garcia-Cordier, Corinne, Megret, Jérôme, te Riele, Hein, Junien, Claudine, Gourdon, Geneviève
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
DNA Dynamics and Chromosome Structure
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC343816/
https://ncbi.nlm.nih.gov/pubmed/14701736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.2.629-637.2004
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki