MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.
Myotonic dystrophy type 1 (DM1) is associated with one of the most highly unstable CTG*CAG repeat expansions. The formation of further repeat expansions in transgenic mice carrying expanded CTG*CAG tracts requires the mismatch repair (MMR) proteins MSH2 and MSH3, forming the MutSbeta complex. It has...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2009-05-01
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| Series: | PLoS Genetics |
| Acceso en liña: | http://europepmc.org/articles/PMC2674216?pdf=render |
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