The highly conserved 5' untranslated region as an effective target towards the inhibition of Enterovirus 71 replication by unmodified and appropriate 2'-modified siRNAs

BACKGROUND: Enterovirus 71 (EV71) is a highly infectious agent that plays an etiological role in hand, foot, and mouth disease. It is associated with severe neurological complications and has caused significant mortalities in recent large-scale outbreaks. Currently, no effective vaccine or specific...

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Detalhes bibliográficos
Main Authors: Deng, Jun-Xia, Nie, Xiao-Jing, Lei, Ying-Feng, Ma, Chao-Feng, Xu, Dong-Liang, Li, Biao, Xu, Zhi-Kai, Zhang, Guo-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438048/
https://ncbi.nlm.nih.gov/pubmed/22889374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-19-73
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