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Ubiquitination of Ras enhances activation and facilitates binding to select downstream effectors
GTP-loaded Ras induces multiple signaling pathways by binding to its numerous effectors such as Raf and PI3K. Ras activity can be influenced by activation of Ras-GEFs that stimulate GDP release and GTP loading or by inhibition of Ras-GAPs that stimulate GTP hydrolysis. Here, we report that monoubiqu...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437993/ https://ncbi.nlm.nih.gov/pubmed/21386094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001518 |
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