Hoxa9 and Meis1 Are Key Targets for MLL-ENL-Mediated Cellular Immortalization

MLL fusion proteins are oncogenic transcription factors that are associated with aggressive lymphoid and myeloid leukemias. We constructed an inducible MLL fusion, MLL-ENL-ERtm, that rendered the transcriptional and transforming properties of MLL-ENL strictly dependent on the presence of 4-hydroxy-t...

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Détails bibliographiques
Auteurs principaux: Zeisig, Bernd B., Milne, Tom, García-Cuéllar, María-Paz, Schreiner, Silke, Martin, Mary-Ellen, Fuchs, Uta, Borkhardt, Arndt, Chanda, Sumit K., Walker, John, Soden, Richard, Hess, Jay L., Slany, Robert K.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2004
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC343796/
https://ncbi.nlm.nih.gov/pubmed/14701735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.2.617-628.2004
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