Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes

MLL fusions are leukemogenic transcription factors that enhance transcriptional elongation through modification of chromatin and RNA Pol II. Global transcription rates and chromatin changes accompanying the transformation process induced by MLL-ENL were monitored by nascent RNA-seq and ChIP-seq, rev...

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Detalhes bibliográficos

Principais autores:	Maria-Paz Garcia-Cuellar, Christian Büttner, Christoph Bartenhagen, Martin Dugas, Robert K. Slany
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-04-01
coleção:	Cell Reports
Assuntos:	leukemia chromatin MLL-ENL P-TEFb DOT1L inhibitors
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124716302595
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