Restoring de novo Coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous Coenzyme Q supplementation

Coenzyme Q (ubiquinone or Q) is an essential lipid component of the mitochondrial electron transport chain. In Caenorhabditis elegans Q biosynthesis involves at least nine steps, including the hydroxylation of the hydroquinone ring by CLK-1 and two O-methylation steps mediated by COQ-3. We character...

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Bibliografiset tiedot
Päätekijät: Gomez, Fernando, Saiki, Ryoichi, Chin, Randall, Srinivasan, Chandra, Clarke, Catherine F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437764/
https://ncbi.nlm.nih.gov/pubmed/22735617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2012.06.023
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