Restoring de novo Coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous Coenzyme Q supplementation

Por Gomez, Fernando, Saiki, Ryoichi, Chin, Randall, Srinivasan, Chandra, Clarke, Catherine F.
Publicado em 2012

Target identification using drug affinity responsive target stability (DARTS)

Por Lomenick, Brett, Hao, Rui, Jonai, Nao, Chin, Randall M., Aghajan, Mariam, Warburton, Sarah, Wang, Jianing, Wu, Raymond P., Gomez, Fernando, Loo, Joseph A., Wohlschlegel, James A., Vondriska, Thomas M., Pelletier, Jerry, Herschman, Harvey R., Clardy, Jon, Clarke, Catherine F., Huang, Jing
Publicado em 2009

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

Por Fu, Xudong, Chin, Randall M., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Xing, Yanpeng, Pai, Melody Y., Li, Sichen, Ta, Lisa, Fazlollahi, Farbod, Chen, Chuo, Prins, Robert M., Teitell, Michael A., Nathanson, David A., Lai, Albert, Faull, Kym F., Jiang, Meisheng, Clarke, Steven G., Cloughesy, Timothy F., Graeber, Thomas G., Braas, Daniel, Christofk, Heather R., Jung, Michael E., Reue, Karen, Huang, Jing
Publicado no Cell Metab (2015)

The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR

Por Chin, Randall M., Fu, Xudong, Pai, Melody Y., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S., Monsalve, Gabriela C., Hu, Eileen, Whelan, Stephen A., Wang, Jennifer X., Jung, Gwanghyun, Solis, Gregory M., Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S., Godwin, Hilary A., Chang, Helena R., Faull, Kym F., Guo, Feng, Jiang, Meisheng, Trauger, Sunia A., Saghatelian, Alan, Braas, Daniel, Christofk, Heather R., Clarke, Catherine F., Teitell, Michael A., Petrascheck, Michael, Reue, Karen, Jung, Michael E., Frand, Alison R., Huang, Jing
Publicado no Nature (2014)