Gene Transfer to the CNS Is Efficacious in Immune-primed Mice Harboring Physiologically Relevant Titers of Anti-AAV Antibodies

Central nervous system (CNS)-directed gene therapy with recombinant adeno-associated virus (AAV) vectors has been used effectively to slow disease course in mouse models of several neurodegenerative diseases. However, these vectors were typically tested in mice without prior exposure to the virus, a...

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Main Authors: Treleaven, Christopher M, Tamsett, Thomas J, Bu, Jie, Fidler, Jonathan A, Sardi, S Pablo, Hurlbut, Gregory D, Woodworth, Lisa A, Cheng, Seng H, Passini, Marco A, Shihabuddin, Lamya S, Dodge, James C
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437584/
https://ncbi.nlm.nih.gov/pubmed/22735381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.114
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