Comparative Analysis of Acid Sphingomyelinase Distribution in the CNS of Rats and Mice Following Intracerebroventricular Delivery

Niemann-Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity. Previously, we reported that biochemical and functional abnormalities observed in ASM knockout (ASMKO) mice could be partially alleviated by intracerebroventricular (ICV...

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Detalhes bibliográficos
Main Authors: Treleaven, Christopher M., Tamsett, Thomas, Fidler, Jonathan A., Taksir, Tatyana V., Cheng, Seng H., Shihabuddin, Lamya S., Dodge, James C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026829/
https://ncbi.nlm.nih.gov/pubmed/21283548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016313
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