Ad3-hTERT-E1A, a Fully Serotype 3 Oncolytic Adenovirus, in Patients With Chemotherapy Refractory Cancer

Twenty-five patients with chemotherapy refractory cancer were treated with a fully serotype 3-based oncolytic adenovirus Ad3-hTERT-E1A. In mice, Ad3 induced higher amounts of cytokines but less liver damage than Ad5 or Ad5/3. In humans, the only grade 3 adverse reactions were self-limiting cytopenia...

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Detalhes bibliográficos
Main Authors: Hemminki, Otto, Diaconu, Iulia, Cerullo, Vincenzo, Pesonen, Saila K, Kanerva, Anna, Joensuu, Timo, Kairemo, Kalevi, Laasonen, Leena, Partanen, Kaarina, Kangasniemi, Lotta, Lieber, Andre, Pesonen, Sari, Hemminki, Akseli
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437574/
https://ncbi.nlm.nih.gov/pubmed/22871667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.115
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