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Genes involved in differentiation, stem cell renewal and tumorigenesis are modulated in telomerase-immortalized human urothelial cells
Expression of hTERT, the catalytic subunit of telomerase, immortalizes normal human urothelial cells (NHUC). Expression of a modified hTERT, without the ability to act in telomere maintenance did not immortalize NHUC, confirming that effects at telomeres are required for urothelial immortalization....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437422/ https://ncbi.nlm.nih.gov/pubmed/18644980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-07-2168 |
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