Autocatalytic Nitration of Prostaglandin Endoperoxide Synthase-2 by Nitrite Inhibits Prostanoid Formation in Rat Alveolar Macrophages

Aims: Prostaglandin endoperoxide H(2) synthase (PGHS) is a well-known target for peroxynitrite-mediated nitration. In several experimental macrophage models, however, the relatively late onset of nitration failed to coincide with the early peak of endogenous peroxynitrite formation. In the present w...

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Detalhes bibliográficos
Main Authors: Schildknecht, Stefan, Karreman, Christiaan, Daiber, Andreas, Zhao, Cheng, Hamacher, Jürg, Perlman, David, Jung, Birgit, van der Loo, Bernd, O'Connor, Peter, Leist, Marcel, Ullrich, Volker, Bachschmid, Markus Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437048/
https://ncbi.nlm.nih.gov/pubmed/22578329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4485
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