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Serine Protease Inhibition by a Silanediol Peptidomimetic
[Image: see text] Silanediol peptidomimetics are demonstrated to inhibit a serine protease. Asymmetric synthesis of the inhibitor was accomplished using Brown hydroboration and CBS reduction of an acylsilane intermediate. The silanediol product was found to inhibit the serine protease chymotrypsin w...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437013/ https://ncbi.nlm.nih.gov/pubmed/22894760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol301933n |
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