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4-1BB Controls Regulatory Activity in Dendritic Cells through Promoting Optimal Expression of Retinal Dehydrogenase

Dendritic cells (DC) in the gut promote immune tolerance by expressing retinal dehydrogenase (RALDH), an enzyme that promotes retinoic acid (RA), which aids differentiation of inducible Foxp3+ Treg (iTreg) in the intestinal mucosa. How RALDH expression is regulated is unclear. We found that 4-1BB (C...

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Detalhes bibliográficos
Main Authors: Lee, Seung-Woo, Park, Yunji, Eun, So-Young, Madireddi, Shravan, Cheroutre, Hilde, Croft, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436963/
https://ncbi.nlm.nih.gov/pubmed/22896640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201248
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