Opportunities and Challenges for use of Tumor Spheroids as Models to Test Drug Delivery and Efficacy

Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current article examines the suitability of spheroids as an in vitro platform for testing drug delivery systems. Spheroids model critical physiologic parameters present in vivo, including complex multicellular arch...

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Hauptverfasser: Mehta, Geeta, Hsiao, Amy Y., Ingram, Marylou, Luker, Gary D., Takayama, Shuichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436947/
https://ncbi.nlm.nih.gov/pubmed/22613880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.04.045
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