Distinct Functional Patterns of Gene Promoter Hypomethylation and Hypermethylation in Cancer Genomes

BACKGROUND: Aberrant DNA methylation plays important roles in carcinogenesis. However, the functional significance of genome-wide hypermethylation and hypomethylation of gene promoters in carcinogenesis currently remain unclear. PRINCIPAL FINDINGS: Based on genome-wide methylation data for five canc...

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Main Authors: Shen, Xiaopei, He, Zheng, Li, Hongdong, Yao, Chen, Zhang, Yang, He, Lang, Li, Shan, Huang, Jian, Guo, Zheng
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436878/
https://ncbi.nlm.nih.gov/pubmed/22970311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044822
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