PARADIGM-SHIFT predicts the function of mutations in multiple cancers using pathway impact analysis

Motivation: A current challenge in understanding cancer processes is to pinpoint which mutations influence the onset and progression of disease. Toward this goal, we describe a method called PARADIGM-SHIFT that can predict whether a mutational event is neutral, gain-or loss-of-function in a tumor sa...

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Autores principales: Ng, Sam, Collisson, Eric A., Sokolov, Artem, Goldstein, Theodore, Gonzalez-Perez, Abel, Lopez-Bigas, Nuria, Benz, Christopher, Haussler, David, Stuart, Joshua M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
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Original Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436829/
https://ncbi.nlm.nih.gov/pubmed/22962493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bts402
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