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PARADIGM-SHIFT predicts the function of mutations in multiple cancers using pathway impact analysis
Motivation: A current challenge in understanding cancer processes is to pinpoint which mutations influence the onset and progression of disease. Toward this goal, we describe a method called PARADIGM-SHIFT that can predict whether a mutational event is neutral, gain-or loss-of-function in a tumor sa...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3436829/ https://ncbi.nlm.nih.gov/pubmed/22962493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bts402 |
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