PARADIGM-SHIFT predicts the function of mutations in multiple cancers using pathway impact analysis

Motivation: A current challenge in understanding cancer processes is to pinpoint which mutations influence the onset and progression of disease. Toward this goal, we describe a method called PARADIGM-SHIFT that can predict whether a mutational event is neutral, gain-or loss-of-function in a tumor sa...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Ng, Sam, Collisson, Eric A., Sokolov, Artem, Goldstein, Theodore, Gonzalez-Perez, Abel, Lopez-Bigas, Nuria, Benz, Christopher, Haussler, David, Stuart, Joshua M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Original Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436829/
https://ncbi.nlm.nih.gov/pubmed/22962493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bts402
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi