Structural basis of LaDR5, a novel agonistic anti-death receptor 5 (DR5) monoclonal antibody, to inhibit DR5/TRAIL complex formation

BACKGROUND: As a member of the TNF superfamily, TRAIL could induce human tumor cell apoptosis through its cognate death receptors DR4 or DR5, which can induce formation of the death inducing signaling complex (DISC) and activation of the membrane proximal caspases (caspase-8 or caspase-10) and mitoc...

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Main Authors: Qiao, Chunxia, Hu, Meiyun, Guo, Leiming, Lv, Ming, Lin, Zhou, Geng, Jing, Lang, Xiaoling, Li, Xinying, Li, Yan, Ma, Yuanfang, Feng, Jiannan, Shen, Beifen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436762/
https://ncbi.nlm.nih.gov/pubmed/22788777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-13-40
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