Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition

NF-κB-mediated inflammation is the major pathology in chronic kidney diseases, including HIV-associated nephropathy (HIVAN) that ultimately progresses to end stage renal disease. HIV infection in the kidney induces NF-κB activation, leading to the production of proinflammatory chemokines, cytokines,...

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Detalhes bibliográficos
Main Authors: Zhang, Guangtao, Liu, Ruijie, Zhong, Yifei, Plotnikov, Alexander N., Zhang, Weijia, Zeng, Lei, Rusinova, Elena, Gerona-Nevarro, Guillermo, Moshkina, Natasha, Joshua, Jennifer, Chuang, Peter Y., Ohlmeyer, Michael, He, John Cijiang, Zhou, Ming-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436579/
https://ncbi.nlm.nih.gov/pubmed/22645123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359505
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