Chemically Programmed Bispecific Antibodies That Recruit and Activate T Cells

Bispecific antibodies (biAbs) that mediate cytotoxicity by recruiting and activating endogenous immune cells are an emerging class of next-generation antibody therapeutics. Of particular interest are biAbs of relatively small size (∼50 kDa) that can redirect cytotoxic T cells through simultaneous bi...

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Bibliografiske detaljer
Main Authors: Cui, Huiting, Thomas, Joshua D., Burke, Terrence R., Rader, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436515/
https://ncbi.nlm.nih.gov/pubmed/22761439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.384594
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