Fas-associated Factor 1 Is a Scaffold Protein That Promotes β-Transducin Repeat-containing Protein (β-TrCP)-mediated β-Catenin Ubiquitination and Degradation

FAS-associated factor 1 (FAF1) antagonizes Wnt signaling by stimulating β-catenin degradation. However, the molecular mechanism underlying this effect is unknown. Here, we demonstrate that the E3 ubiquitin ligase β-transducin repeat-containing protein (β-TrCP) is required for FAF1 to suppress Wnt si...

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Hlavní autoři: Zhang, Long, Zhou, Fangfang, Li, Yihao, Drabsch, Yvette, Zhang, Juan, van Dam, Hans, ten Dijke, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436314/
https://ncbi.nlm.nih.gov/pubmed/22730322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.353524
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