Fibroblast Growth Factor Receptor 2 Homodimerization Rapidly Reduces Transcription of the Pluripotency Gene Nanog without Dissociation of Activating Transcription Factors

Nanog or Gata6-positive cells co-exist and are convertible within the inner cell mass of murine blastocysts and embryonic stem (ES) cells. Previous studies demonstrate fibroblast growth factor receptor 2 (FGFR2) triggers Nanog gene down-regulation and differentiation to primitive endoderm (PE); howe...

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Main Authors: Santostefano, Katherine E., Hamazaki, Takashi, Pardo, Carolina E., Kladde, Michael P., Terada, Naohiro
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Developmental Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436299/
https://ncbi.nlm.nih.gov/pubmed/22787153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.388181
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