The impact of cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index

BACKGROUND: Mantle cell lymphoma is a clinically heterogeneous disease characterized by overexpression of cyclin D1 protein. Blastoid morphology, high proliferation, and secondary genetic aberrations are markers of aggressive behavior. Expression profiling of mantle cell lymphoma revealed that predo...

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Detalhes bibliográficos
Main Authors: Slotta-Huspenina, Julia, Koch, Ina, de Leval, Laurence, Keller, Gisela, Klier, Margit, Bink, Karin, Kremer, Marcus, Raffeld, Mark, Fend, Falko, Quintanilla-Martinez, Leticia
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436245/
https://ncbi.nlm.nih.gov/pubmed/22315488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.055715
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