Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

To determine whether the PI3K/Akt signaling pathway is involved in the pathogenesis of mantle cell lymphoma (MCL), we investigated the phosphorylation status of Akt and multiple downstream targets in primary MCL cases and cell lines. Akt was phosphorylated in 12 of 12 aggressive blastoid MCL variant...

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Detalhes bibliográficos
Main Authors: Rudelius, Martina, Pittaluga, Stefania, Nishizuka, Satoshi, Pham, Trinh H.-T., Fend, Falko, Jaffe, Elaine S., Quintanilla-Martinez, Leticia, Raffeld, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895501/
https://ncbi.nlm.nih.gov/pubmed/16645163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-015586
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