Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

To determine whether the PI3K/Akt signaling pathway is involved in the pathogenesis of mantle cell lymphoma (MCL), we investigated the phosphorylation status of Akt and multiple downstream targets in primary MCL cases and cell lines. Akt was phosphorylated in 12 of 12 aggressive blastoid MCL variant...

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Autores principales: Rudelius, Martina, Pittaluga, Stefania, Nishizuka, Satoshi, Pham, Trinh H.-T., Fend, Falko, Jaffe, Elaine S., Quintanilla-Martinez, Leticia, Raffeld, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: © 2006 by The American Society of Hematology 2006
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895501/
https://ncbi.nlm.nih.gov/pubmed/16645163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-015586
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