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Erythroid lineage-restricted expression of Jak2V617F is sufficient to induce a myeloproliferative disease in mice
The JAK2V617F mutation has been found in most cases of Ph-negative myeloproliferative neoplasms. Recent studies have shown that expression of Jak2V617F in the hematopoietic compartment causes marked expansion of erythroid progenitors and their transformation to cytokine-independence. To determine if...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Ferrata Storti Foundation
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3436240/ https://ncbi.nlm.nih.gov/pubmed/22371173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.059113 |
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