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Erythroid lineage-restricted expression of Jak2V617F is sufficient to induce a myeloproliferative disease in mice

The JAK2V617F mutation has been found in most cases of Ph-negative myeloproliferative neoplasms. Recent studies have shown that expression of Jak2V617F in the hematopoietic compartment causes marked expansion of erythroid progenitors and their transformation to cytokine-independence. To determine if...

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Main Authors: Akada, Hajime, Akada, Saeko, Hutchison, Robert E., Mohi, Golam
格式: Artigo
語言:Inglês
出版: Ferrata Storti Foundation 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436240/
https://ncbi.nlm.nih.gov/pubmed/22371173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.059113
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