Fatty Acids Bind Tightly to the N-terminal Domain of Angiopoietin-like Protein 4 and Modulate Its Interaction with Lipoprotein Lipase

Angiopoietin-like protein 4 (Angptl4), a potent regulator of plasma triglyceride metabolism, binds to lipoprotein lipase (LPL) through its N-terminal coiled-coil domain (ccd-Angptl4) inducing dissociation of the dimeric enzyme to inactive monomers. In this study, we demonstrate that fatty acids redu...

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Bibliographic Details
Main Authors: Robal, Terje, Larsson, Mikael, Martin, Miina, Olivecrona, Gunilla, Lookene, Aivar
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436166/
https://ncbi.nlm.nih.gov/pubmed/22773878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.303529
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