Assessment of Anti-recombination and Double-strand Break-induced Gene Conversion in Human Cells by a Chromosomal Reporter

Gene conversion is one of the frequent end results of homologous recombination, and it often underlies the inactivation of tumor suppressor genes in cancer cells. Here, we have developed an integrated assay system that allows simultaneous examination of double-strand break (DSB)-induced gene convers...

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Bibliographic Details
Main Authors: Xu, Keqian, Wu, Xiling, Tompkins, Joshua D., Her, Chengtao
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436158/
https://ncbi.nlm.nih.gov/pubmed/22773873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.352302
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