Protein Kinase Cα (PKCα) Regulates p53 Localization and Melanoma Cell Survival Downstream of Integrin αv in Three-dimensional Collagen and in Vivo

Protein kinase C α (PKCα) is overexpressed in numerous types of cancer. Importantly, PKCα has been linked to metastasis of malignant melanoma in patients. However, it has been unclear how PKCα may be regulated and how it exerts its role in melanoma. Here, we identified a role for PKCα in melanoma ce...

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Autores principales: Smith, Stephen D., Enge, Martin, Bao, Wenjie, Thullberg, Minna, Costa, Tânia D. F., Olofsson, Helene, Gashi, Behxhet, Selivanova, Galina, Strömblad, Staffan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436133/
https://ncbi.nlm.nih.gov/pubmed/22773839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341917
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