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Biocatalytic production of tetrahydroisoquinolines
The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of te...
Wedi'i Gadw mewn:
Prif Awduron: | , , |
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Fformat: | Artigo |
Iaith: | Inglês |
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2012
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435518/ https://ncbi.nlm.nih.gov/pubmed/22966211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2011.12.089 |
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