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Biocatalytic production of tetrahydroisoquinolines
The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of te...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435518/ https://ncbi.nlm.nih.gov/pubmed/22966211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2011.12.089 |
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