Reverse Phase Protein Array Profiling Reveals Distinct Proteomic Signatures Associated With Chronic Myeloid Leukemia Progression and With Chronic Phase in the CD34-Positive Compartment

BACKGROUND: Chronic myeloid leukemia (CML) is a clonal stem cell malignancy whose pathogenesis is driven by constitutive activation of the breakpoint cluster region–v-abl Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL1) kinase. Although BCR-ABL1 activation is present in all patients with...

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Bibliographic Details
Main Authors: Quintás-Cardama, Alfonso, Qiu, Yi Hua, Post, Sean M., Zhang, Yiqun, Creighton, Chad J., Cortes, Jorge, Kornblau, Steven M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435477/
https://ncbi.nlm.nih.gov/pubmed/22517119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.27568
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