The synthesis of the internucleotide (phosphodiester) bond by a base-catalysed reaction.
Potassium tert-butoxide in hexamethyl phosphoramide and dimethyl formamide provides an excellent catalyst for the reaction of a 3'-hydroxyl or a 5'-hydroxyl group of a nucleoside with an appropriate nucleoside phosphorofluoridate to yield the dinucleoside phosphate. This paper describes the experime...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
1975
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| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC343540/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/171626/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/2.10.1727 |
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