A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis

BACKGROUND: Fulminant hepatitis progresses to acute liver failure (ALF) when the extent of hepatocyte death exceeds the liver's regenerative capacity. Although small interfering RNA (siRNA) appears promising in animal models of hepatitis, the approach is limited by drawbacks associated with sys...

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Detalhes bibliográficos
Main Authors: Jiang, Nan, Zhang, Xusheng, Zheng, Xiufen, Chen, Di, Siu, Kingsun, Wang, Hongmei, Ichim, Thomas E., Quan, Douglas, McAlister, Vivian, Chen, Guihua, Min, Wei-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435394/
https://ncbi.nlm.nih.gov/pubmed/22970170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044138
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