MicroRNA-16 Is Down-Regulated in Mutated FLT3 Expressing Murine Myeloid FDC-P1 Cells and Interacts with Pim-1

Activating mutations in the receptor tyrosine kinase FLT3 are one of the most frequent somatic mutations in acute myeloid leukemia (AML). Internal tandem duplications of the juxtamembrane region of FLT3 (FLT3/ITD) constitutively activate survival and proliferation pathways, and are associated with a...

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Main Authors: Kim, Kyu-Tae, Carroll, Adam P., Mashkani, Baratali, Cairns, Murray J., Small, Donald, Scott, Rodney J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435263/
https://ncbi.nlm.nih.gov/pubmed/22970245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044546
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