Unbiased Mutagenesis of MHV68 LANA Reveals a DNA-Binding Domain Required for LANA Function In Vitro and In Vivo

The Latency-Associated Nuclear Antigen (LANA), encoded by ORF73, is a conserved gene among the γ2-herpesviruses (rhadinoviruses). The Kaposi's Sarcoma-Associated Herpesvirus (KSHV) LANA is consistently expressed in KSHV-associated malignancies. In the case of the rodent γ2-herpesvirus, murine g...

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Bibliographic Details
Main Authors: Paden, Clinton R., Forrest, J. Craig, Tibbetts, Scott A., Speck, Samuel H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435236/
https://ncbi.nlm.nih.gov/pubmed/22969427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002906
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