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Activation of the noncanonical NF-κB pathway by HIV controls a dendritic cell immunoregulatory phenotype
HIV modulates plasmacytoid dendritic cell (pDC) activation via Toll-like receptor 7, inducing type I IFN and inflammatory cytokines. Simultaneously, pDCs up-regulate the expression of indoleamine 2,3 dioxygenase (IDO), which is essential for the induction of regulatory T cells (Tregs), which functio...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435221/ https://ncbi.nlm.nih.gov/pubmed/22879398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204032109 |
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