Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

Glioblastoma multiforme (GBM) is the most aggressive of the astrocytic malignancies and the most common intracranial tumor in adults. Although the epidermal growth factor receptor (EGFR) is overexpressed and/or mutated in at least 50% of GBM cases and is required for tumor maintenance in animal mode...

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Bibliographic Details
Main Authors: Fenton, Tim R., Nathanson, David, Ponte de Albuquerque, Claudio, Kuga, Daisuke, Iwanami, Akio, Dang, Julie, Yang, Huijun, Tanaka, Kazuhiro, Oba-Shinjo, Sueli Mieko, Uno, Miyuki, del Mar Inda, Maria, Wykosky, Jill, Bachoo, Robert M., James, C. David, DePinho, Ronald A., Vandenberg, Scott R., Zhou, Huilin, Marie, Suely K. N., Mischel, Paul S., Cavenee, Webster K., Furnari, Frank B.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435194/
https://ncbi.nlm.nih.gov/pubmed/22891331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211962109
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