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Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development

Congenital heart disease (CHD) occurs in ∼1% of newborns. CHD arises from many distinct etiologies, ranging from genetic or genomic variation to exposure to teratogens, which elicit diverse cell and molecular responses during cardiac development. To systematically explore the relationships between C...

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Autors principals: Lage, Kasper, Greenway, Steven C., Rosenfeld, Jill A., Wakimoto, Hiroko, Gorham, Joshua M., Segrè, Ayellet V., Roberts, Amy E., Smoot, Leslie B., Pu, William T., C. Pereira, Alexandre, Mesquita, Sonia M., Tommerup, Niels, Brunak, Søren, Ballif, Blake C., Shaffer, Lisa G., Donahoe, Patricia K., Daly, Mark J., Seidman, Jonathan G., Seidman, Christine E., Larsen, Lars A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435181/
https://ncbi.nlm.nih.gov/pubmed/22904188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1210730109
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