Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca(2+) signaling and high-frequency hearing acquisition

Phosphatidylinositol phosphate kinase type 1γ (PIPKIγ) is a key enzyme in the generation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] and is expressed at high levels in the nervous system. Homozygous knockout mice lacking this enzyme die postnatally within 24 h, whereas PIPKIγ(+/−) sibling...

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Hlavní autoři: Rodriguez, Laura, Simeonato, Elena, Scimemi, Pietro, Anselmi, Fabio, Calì, Bianca, Crispino, Giulia, Ciubotaru, Catalin D., Bortolozzi, Mario, Ramirez, Fabian Galindo, Majumder, Paromita, Arslan, Edoardo, De Camilli, Pietro, Pozzan, Tullio, Mammano, Fabio
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435166/
https://ncbi.nlm.nih.gov/pubmed/22891314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211869109
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