Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation

The role of NF-κB activation in tumor initiation has not been thoroughly investigated. We generated Ikkβ(EE)(IEC) transgenic mice expressing constitutively active IκB kinase β (IKKβ) in intestinal epithelial cells (IECs). Despite absence of destructive colonic inflammation, Ikkβ(EE)(IEC) mice develo...

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Main Authors: Shaked, Helena, Hofseth, Lorne J., Chumanevich, Alena, Chumanevich, Alexander A., Wang, Jin, Wang, Yinsheng, Taniguchi, Koji, Guma, Monica, Shenouda, Steve, Clevers, Hans, Harris, Curtis C., Karin, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435160/
https://ncbi.nlm.nih.gov/pubmed/22893683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211509109
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