Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

Nuclear factor (NF)-κB, activated by IκB kinase (IKK), is a key regulator of inflammation, innate immunity, and tissue integrity. NF-κB and one of its main activators and transcriptional targets, tumor necrosis factor (TNF), are up-regulated in many inflammatory diseases that are accompanied by tiss...

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Main Authors: Guma, Monica, Stepniak, Dariusz, Shaked, Helena, Spehlmann, Martina E., Shenouda, Steve, Cheroutre, Hilde, Vicente-Suarez, Ildelfonso, Eckmann, Lars, Kagnoff, Martin F., Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171091/
https://ncbi.nlm.nih.gov/pubmed/21825016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20110242
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