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Formation of internucleotide 3'-5' phosphoramidate links by direct coupling of phosphoryl and amino groups.

The stepwise synthesis of oligomers derived from 5'-amino-5'-deoxythymidine 3'-phosphate and 5'-amino-5'-deoxy-3'-O-mono-p-methoxytrityl-thymidine is described. The internucleotide phosphoramidate links were formed by condensation of nucleoside 3'-phosphates with a...

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Detalhes bibliográficos
Main Authors: Greene, G L, Letsinger, R L
Formato: Artigo
Idioma:Inglês
Publicado em: 1975
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC343499/
https://ncbi.nlm.nih.gov/pubmed/1153331
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