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Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy

The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic changes that stimulate tissue repair and regeneration in normal cells but can be co-opted during tumor growth. MET overexpr...

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Main Authors: Blumenschein, George R., Mills, Gordon B., Gonzalez-Angulo, Ana M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society of Clinical Oncology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434988/
https://ncbi.nlm.nih.gov/pubmed/22869872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.40.3774
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