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Targeting the Hepatocyte Growth Factor–cMET Axis in Cancer Therapy

The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic changes that stimulate tissue repair and regeneration in normal cells but can be co-opted during tumor growth. MET overexpr...

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Autori principali: Blumenschein, George R., Mills, Gordon B., Gonzalez-Angulo, Ana M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434988/
https://ncbi.nlm.nih.gov/pubmed/22869872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.40.3774
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