Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

Many neuroprotective agents have been effective in experimental stroke, yet few have translated into clinical application. One reason for this may be failure to consider clinical comorbidities/risk factors in experimental models. We have shown that a naturally occurring interleukin-1 receptor antago...

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Autors principals: Pradillo, Jesus M, Denes, Adam, Greenhalgh, Andrew D, Boutin, Herve, Drake, Caroline, McColl, Barry W, Barton, Eleanor, Proctor, Spencer D, Russell, James C, Rothwell, Nancy J, Allan, Stuart M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434631/
https://ncbi.nlm.nih.gov/pubmed/22781338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.101
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