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Design of Meningococcal Factor H Binding Protein Mutant Vaccines That Do Not Bind Human Complement Factor H

Meningococcal factor H binding protein (fHbp) is a human species-specific ligand for the complement regulator, factor H (fH). In recent studies, fHbp vaccines in which arginine at position 41 was replaced by serine (R41S) had impaired fH binding. The mutant vaccines elicited bactericidal responses i...

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Bibliografiske detaljer
Main Authors: Pajon, Rolando, Beernink, Peter T., Granoff, Dan M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434564/
https://ncbi.nlm.nih.gov/pubmed/22615247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00103-12
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