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Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. Although novel drugs against HCV are under development, the current standard therapy consists principally of interferon (IFN). To improve the response to IFN treatment by enhancing interferon-stimulated response e...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Yoshikawa, Takeshi, Takata, Akemi, Otsuka, Motoyuki, Kishikawa, Takahiro, Kojima, Kentaro, Yoshida, Haruhiko, Koike, Kazuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434395/
https://ncbi.nlm.nih.gov/pubmed/22957141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00637
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